Preprothrombin and Prothrombin in Full-Term Newborns

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Abstract
Three activities of factor II (prothrombin, prothrombin-coagulase and antigenic activity) have been evaluated in full-term newborns on the first 5 days of life. Prothrombin activity is similar to prothrombin-coagulase activity on the 1st day of life and on the 3rd day the two activities decrease simultaneously. The prothrombin activity rises again towards the 5th day, contrary to the prothrombin-coagulase activity which continues to decrease. If vitamin K1 is not administered, the decrease in the two activities on the 3rd day is more marked. The antigenic activity of factor II does not show significant variations from the 1st to the 5th day of life; it always remains inferior to the values observed in adults.

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