STEROID-HORMONE SECRETION FROM A VIRILIZING LIPOID CELL TUMOR OF THE OVARY

  • 1 January 1981
    • journal article
    • research article
    • Vol. 57  (4) , 525-531
Abstract
The case of a 23 yr old woman with a virilizing lipoid cell tumor of the ovary is reported. The patient developed precocious puberty at age 4 and from age 5-10 yr was treated weekly with i.m. medroxyprogesterone acetate. She began to menstruate spontaneously at age 13 but developed hirsutism, acne and irregular menses at age 15 followed by secondary amenorrhea at age 20. Steroid analyses demonstrated elevated peripheral plasma levels of testosterone, dihydrotestosterone, androstenedione, 17.alpha.-hydroxyprogesterone, progesterone, desoxycorticosterone, estrone and estradiol. Catheterization of the adrenal and ovarian veins revealed increased secretion of testosterone, dehydroepiandrosterone, androstenedione, 17.alpha.-hydroxyprogesterone, progesterone, desoxycorticosterone, corticosterone, 11-deoxycortisol, cortisol, estrone and estradiol from the right ovarian vein. At surgery a right ovarian lipoid cell tumor was removed. Incubation studies with the tumor tissue confirmed the presence of gonadal and adrenocortical steroids. The tissue also contained high-affinity human chorionic gonadotropin-luteinizing hormone binding sites with normal binding affinity.

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