HLA and Graves' Disease or Diabetes Mellitus in Japan
- 16 March 1978
- journal article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 298 (11) , 630-631
- https://doi.org/10.1056/nejm197803162981117
Abstract
To the Editor: A significant increase in the incidence of HLA-B8 and Dw3 has been reported in white patients with several autoimmune diseases, including juvenile-onset diabetes mellitus1 and Graves' disease.2 , 3 Two possibilities to explain this phenomenon have been proposed.4 In the first, these two different organ-specific autoimmune diseases might be associated with the same allele of the same gene, and there might be a common initiating pathogenic event in these diseases; secondly, each of these diseases might be associated with a particular allele of different genes, both of which are in linkage disequilibrium with HLA-B8 and HLA-Dw3.Sasazuki et al. . . .Keywords
This publication has 3 references indexed in Scilit:
- HLA-D Antigens in the Japanese PopulationTissue Antigens, 1977
- The Association Between Genes in the Major Histocompatibility Complex and Disease SusceptibilityAnnual Review of Medicine, 1977
- HL-A Antigens as Markers for Disease Susceptibility and Autoimmunity in Graves' DiseaseJournal of Clinical Endocrinology & Metabolism, 1974