Benchtop Monitoring of Reaction Progress via Visual Recognition with a Handheld UV Lamp: In Situ Monitoring of Boronic Acids in the Suzuki−Miyaura Reaction

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Abstract
Although boronic acids are widely used in metal-catalyzed reactions, it is difficult to assay their consumption. As such, we developed a reversible fluorescent sensor that is activated upon binding a boronic acid. The sensor can be used to monitor consumption of a boronic acid in Suzuki−Miyaura reactions. Importantly, only a standard handheld long-wave UV lamp (365 nm) is required and fluorescence is easily detectable with the naked eye without disturbing the reaction mixture.