Time-Dependent Effects of Phenothiazines on Dopamine Turnover in Psychiatric Patients
- 31 October 1975
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 190 (4213) , 488-489
- https://doi.org/10.1126/science.1166321
Abstract
Psychiatric patients studied early during treatment with chlorpromazine and thioridazine demonstrated elevated probenecid-induced accumulations of homovanillic acid, a major dopamine metabolite, in cerebrospinal fluid. In those studied after longer periods of treatment with phenothiazines, homovanillic acid values were not elevated. This suggests that there are time-dependent effects of phenothiazines on dopamine turnover that may be relevant to the time course of antipsychotic efficacy.Keywords
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