Preparation and In Vitro Antibacterial Activity of 9-O-Glycosyloxime Derivatives of Erythromycin A, a New Class of Macrolide Antibiotics.
- 1 January 1996
- journal article
- Published by Japan Antibiotics Research Association in The Journal of Antibiotics
- Vol. 49 (10) , 1036-1043
- https://doi.org/10.7164/antibiotics.49.1036
Abstract
9-O-Glycosyloxime derivatives of erythromycin A have been synthesized and their in vitro antibacterial activity compared with that of erythromycin A (1). This new class of macrolide antibiotics showed reduced antibacterial spectrum. However, some derivatives were as or more active than erythromycin A (1) against strains, responsible for respiratory track infections, such as Haemophilus influenzae, Moraxella catarrhalis or Streptococcus pneumoniae.Keywords
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