Morphological Study of Virus-like Particles in Two Transplantable Tumours from BDX Rats

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Abstract
Virus-like particles were found in 2 transplantable tumors, Sp56 and Sp6, from BDX rats. Sp56k, a neurogenic sarcoma, contains abundant C-type particles in all stages of morphogenesis. This tumor reacts with anti-Friend leukemia virus gp70 and anti-Rauscher leukemia virus p30 sera. Sp6, a fibrosarcoma, had abundant virus-like particles in the cytoplasm, very often associated with centrioles or basal bodies of a cilium. These particles consist of 2 concentric shells with a diameter of 60-65 nm. Released particles found outside the cell had a diameter of 85-100 nm and were characterized by an envelope and an eccentrically located elecron-dense nucleoid, surrounded by an intermediate layer. These virus-like particles show no cross-reaction with antisera against murine C- or B-type particles, but show ultrastructural similarity with virus particles recently described in Chinese hamster cells and in mouse cell lines infected with 2 retrovirus isolates from Southeast Asian mice.

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