Regulation of low density lipoprotein metabolism by 26‐hydroxycholesterol in human fibroblasts
- 22 June 1987
- journal article
- Published by Wiley in FEBS Letters
- Vol. 218 (1) , 77-80
- https://doi.org/10.1016/0014-5793(87)81022-0
Abstract
Oxygenated derivatives of cholesterol are believed to play a role in cellular cholesterol homeostasis through the feed-back control of its biosynthesis. We report that 26-hydroxycholesterol inhibits the specific binding, uptake and degradation of 125I-LDL in human fibroblasts. The effect is dose-dependent, and saturation kinetics indicates a reduction of LDL-binding sites with no effect on ligand affinity. The results support a possible role of 26-hydroxycholesterol, a physiological oxysterol, in the regulation of cellular cholesterol homeostasis.Keywords
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