Effects of Naloxone on Insulin-Induced Release of Pituitary Hormones
- 1 July 1981
- journal article
- research article
- Published by The Endocrine Society in Journal of Clinical Endocrinology & Metabolism
- Vol. 53 (1) , 206-208
- https://doi.org/10.1210/jcem-53-1-206
Abstract
To evaluate the role of endogenous opiates on the regulation of the pituitary hormonal stress response, in 6 normal subjects the insulin-induced secretion of PRL [prolactin], GH [growth hormone] and ACTH with and without naloxone, a specific opiate antagonist, was studied. During hypoglycemia, naloxone infusion reduced plasma PRL levels at 90 min, lowered the overall GH response and enhanced that of ACTH. Endogenous opiates apparently have a modulatory role in the stress-induced secretion of pituitary hormones.This publication has 8 references indexed in Scilit:
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