Epinephrine Metabolism in Mammalian Brain after Intravenous and Intraventricular Administration
- 8 August 1969
- journal article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 165 (3893) , 616-617
- https://doi.org/10.1126/science.165.3893.616
Abstract
Epinephrine given intravenously or intraventricularly has a half-life in the brain of the rat of 2 to 2.5 hours. After intravenous administration of the drug the principal route of metabolism is O-methylation, whereas after intraventricular administration the principal route is conjugation.Keywords
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