5-HT1c receptor is a prominent serotonin receptor subtype in the central nervous system.
- 1 September 1989
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 86 (17) , 6793-6797
- https://doi.org/10.1073/pnas.86.17.6793
Abstract
Neurons in rat central nervous sytem (CNS) that express 5-HT1c receptor mRNA have been localized by in situ hybridization histochemistry. The 5-HT1c receptor is expressed in a wide variety of cortical and subcortical neurons including hippocampal pyramidal neurons, neurons within most of the central monoaminergic cell groups, neurons in thalamic sensory relay nuclei, and neurons involved in the central processing and regulation of nociceptive transmission. Therefore, the 5-HT1c receptor is a prominent but poorly characterized central subclass of serotonin (5-HT) receptor. The distribution of the 5-HT1c receptor within the CNS is considerably more widespread than that of the structurally and functionally related 5-HT2 receptor.This publication has 29 references indexed in Scilit:
- The genomic clone G-21 which resembles a β-adrenergic receptor sequence encodes the 5-HT1A receptorNature, 1988
- Molecular Characterization of a Functional cDNA Encoding the Serotonin 1c ReceptorScience, 1988
- 5-Hydroxytryptamine Receptor SubtypesAnnual Review of Neuroscience, 1988
- A family of receptors coupled to guanine nucleotide regulatory proteinsBiochemistry, 1987
- Regulation of Pro-Opiomelanocortin Gene Transcription in Individual Cell NucleiScience, 1986
- A G Protein Couples Serotonin and GABA B Receptors to the Same Channels in HippocampusScience, 1986
- Serotonin receptors in the human brain. II. Characterization and autoradiographic localization of 5-HT1C and 5-HT2 recognition sitesBrain Research, 1986
- Microinjection of morphine into the periaqueductal gray evokes the release of serotonin from spinal cordBrain Research, 1979
- An autoradiographic analysis of the differential ascending projections of the dorsal and median raphe nuclei in the ratJournal of Comparative Neurology, 1978
- Central Catecholamine Neuron Systems: Anatomy and Physiology of the Dopamine SystemsAnnual Review of Neuroscience, 1978