MIXED LYMPHOCYTE CULTURE RESPONSES IN COMBINED IMMUNODEFICIENCY OF HORSES
- 1 February 1978
- journal article
- research article
- Published by Wolters Kluwer Health in Transplantation
- Vol. 25 (2) , 50-52
- https://doi.org/10.1097/00007890-197802000-00002
Abstract
SUMMARY Combined immunodeficiency in horses is a genetic disorder in which there is a defect in the production of committed B and T lymphocytes. In this study, peripheral blood mononu-clear leukocytes from foals with combined immunodeficiency were examined for their capacity to stimulate and respond in one-way mixed lymphocyte cultures. Irradiated cells from combined immunodeficient foals were uniformly capable of stimulating cells from unrelated horses. However, none were able to respond to allogeneic stimulation. Examination of cells from known carrier horses revealed no difference in capacity to stimulate or to respond in mixed lymphocyte culture compared with noncarrier horses.This publication has 3 references indexed in Scilit:
- Evaluation of adenosine deaminase and other purine salvage pathway enzymes in horses with combined immunodeficiencyInfection and Immunity, 1976
- ALTERATIONS OF THYMUS AND OTHER LYMPHOID-TISSUE IN YOUNG HORSES WITH COMBINED IMMUNODEFICIENCY1976
- ANIMAL-MODEL OF HUMAN DISEASE - COMBINED IMMUNODEFICIENCY (SEVERE), SWISS-TYPE AGAMMAGLOBULINEMIA1975