Studies leading to the large scale synthesis of polyesters using enzymes

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Abstract
The ability of immobilised Candida antarctica lipase to catalyse the condensation of diols and diacids was studied. The range of acids investigated (in condensations with butane-1,4-diol) included adipic, maleic, fumaric, itaconic, (E)-hex-3-enedioic and acetylenedicarboxylic acids, while the diols studied, in condensations with adipic acid, encompassed ethane-, propane-, butane-, pentane- and hexane-diols as well as (Z)-but-2-ene-1,4-diol and but-2-yne-1,4-diol. The oligomerization of hexane-1,6-diol and adipic acid was most facile and was chosen for scale-up. A mechanism for the polycondensation process is proposed.

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