Induction of cytochrome P-450 isozymes upon repeated administration of nifedipine
- 1 April 1991
- journal article
- research article
- Published by Springer Nature in European Journal of Drug Metabolism and Pharmacokinetics
- Vol. 16 (2) , 103-106
- https://doi.org/10.1007/bf03189945
Abstract
In experiments on male Wistar rats it has been found that nifedipine administration at a dose of 10 mg/kg body weight i.p. daily for 20 days did not significantly increase the total amount of cytochrome P-450 but markedly increased the 7α-, 16β- and 6β-hydroxylation of androstendione in liver microsomes, suggesting the induction of cytochromes P-450HA1, P-450UB1, and P-450IQA1, respectively. The induction of cytochrome P-450IHB1 was also confirmed immunochemically with polyclonal antibodies against cytochrome P-450HB1/B2.Keywords
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