A NEW HEMOGLOBIN VARIANT RESEMBLING HEMOGLOBIN E: HEMOGLOBIN E SASKATOON-β22Glu→Lys
- 1 September 1967
- journal article
- Published by Canadian Science Publishing in Canadian Journal of Biochemistry
- Vol. 45 (9) , 1385-1391
- https://doi.org/10.1139/o67-163
Abstract
A new hemoglobin electrophoretically indistinguishable from hemoglobin E is described. It was found in a Canadian woman of mixed Dutch and Scottish parentage and was inherited from the Scottish father. Analysis of the tryptic peptides of the whole globin and of the isolated β chain showed that a substitution of glutamic acid by lysine had occurred at position 22 (B4 in Watson and Kendrew's helical notation) of the β chain. In hemoglobin E there is a similar substitution at position 26 (B8) of the β chain.Keywords
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