Advances in Blood Preservation

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Abstract
The changes which occur in human erythrocytes and plasma in long-term preservation of blood for transfusion have long presented a problem. A system has now been developed employing an endocellular cryophylactic agent to protect the cells and arrest their aging during freezing, storage and thawing. Thawed cells are washed by dilution with sugar solution and reversible agglomeration, which removes extraneous substances. Low titers of anti-A and anti-B antibodies in the resuspended frozen blood make it possible to use specially selected group 0 blood for all recipients. The concept of specific donor selection by statistical need may modify or replace the generally accepted practice of random collection for random need.