LACK OF RELATIONSHIP BETWEEN HEPATIC TOXICITY AND ACETYLATOR PHENOTYPE IN 3000 SOUTH-INDIAN PATIENTS DURING TREATMENT WITH ISONIAZID FOR TUBERCULOSIS
- 1 January 1984
- journal article
- research article
- Published by Elsevier
- Vol. 129 (1) , 58-61
- https://doi.org/10.1164/arrd.1984.129.1.58
Abstract
The incidence of jaundice among 3000 patients with pulmonary tuberculosis and of the activities of serum aspartate aminotransferase among 850 according to their isoniazid acetylator phenotype were studied. The patients were treated with a variety of isoniazid-containing regimens in a series of controlled clinical trials. Evidently, rapid acetylators are no more prone to develop isoniazid-induced hepatic toxicity than are slow acetylators.This publication has 3 references indexed in Scilit:
- PREDISPOSING FACTORS IN HEPATITIS INDUCED BY ISONIAZID-RIFAMPIN TREATMENT OF TUBERCULOSISPublished by Elsevier ,1978
- Risks of Isoniazid TherapyAnnals of Internal Medicine, 1976
- Isoniazid Liver Injury: Clinical Spectrum, Pathology, and Probable PathogenesisAnnals of Internal Medicine, 1976