ASSAY FOR CYCLOBARBITAL, SECOBARBITAL AND PENTOBARBITAL BY MULTIPLE ION DETECTION - KINETICS AFTER A SINGLE DOSE

  • 1 January 1982
    • journal article
    • research article
    • Vol. 20  (4) , 267-269
Abstract
A sensitive assay for the determination of 4 different barbiturates, butabarbital, cyclobarbital, pentobarbital and secobarbital, is described. The barbiturates are determined quantitatively by gas chromatography/mass spectrometry as their dimethylated derivatives. The sensitivity of this simple procedure is limited to 10 .times. 10-6 g/l for cyclo- and secobarbital and 1 .times. 10-6 g/l for pentobarbital in [human] plasma. The assay was used to measure the kinetics of pentobarbital over 6 days after a single 50 mg dose of the sodium salt, and over 3 days for a combined preparation of 25 mg cyclobarbital-calcium and 75 mg secobarbital-sodium. The corresponding barbiturate levels in saliva were determined by the same assay.

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