Platelet Size in Stroke Patients

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Abstract
Background and Purpose Large platelets are more reactive, produce more prothrombotic factors, and aggregate more easily. Platelet size can be readily estimated using automated analyzers, although accurate estimation depends on precise methodology. The disparate results from previous studies of mean platelet volume in cerebral ischemia may be explained by varying methodology. We have studied these variables using a precise methodology in an unselected group of stroke patients and compared them with data from age- and sex-matched control subjects. Methods We studied 58 stroke patients consecutively admitted to a geriatric medical unit. Platelet variables were measured in the acute (6 months) phases of cerebral ischemia and compared with control variables. Control patients, admitted to the same unit, were of similar age and sex and without evidence of acute vascular events. Results Mean platelet volume was higher in acute stroke (11.3 compared with 10.1 fL in control sub...