3-Methylcholanthrene-inhibition of hepatocarcinogenesis in the rat due to 3′ -methyl-4-dimethylaminoazobenzene or 2-acetylaminofluorene: a comparative study

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Abstract
Male Leeds strain rats were given a diet containing either 0.06% 3′-methyl-4-dimethylaminoazobenzene (3′-MeDAB) or 0.05% 2-acetylaminofluorene (2-AAF), alone or together with 0.0067% 3-methylcholanthrene (MeCh). MeCh both reduced the incidence of hepatic neoplasms induced by 3′-MeDAB and delayed their development. With 2-AAF, however, inhibition of hepatocarcinogenesis by MeCh only appeared to operate during the period of treatment; thereafter the incidence of tumours rose rapidly and this was accentuated if dietary MeCh continued to be administered after the period of combined 2-AAF and MeCh treatment, suggesting a secondary, promoting effect of MeCh. In contrast, the inhibition by MeCh of carcinogenesis of Zymbal′s gland due to 2-AAF was almost complete. Thus, in the long term MeCh has different effects upon 3′ -MeDAB and 2-AAF carcinogenesis in the rat liver.

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