A SPECIFIC, HIGH-AFFINITY, LIMITED-CAPACITY ESTROGEN BINDING COMPONENT IN THE CYTOSOL OF HUMAN FETAL PITUITARY AND BRAIN TISSUES
- 1 May 1975
- journal article
- other
- Published by The Endocrine Society in Journal of Clinical Endocrinology & Metabolism
- Vol. 40 (5) , 909-912
- https://doi.org/10.1210/jcem-40-5-909
Abstract
A macromolecular component which binds 3H-estradiol with high affinity and limited capacity is present in the 150,000x g supernatant fractions of pituitary, hypothalamus, cortex, and limbic system of both male and female human fetuses. 17β-estradiol and 17α-ethinylestradiol effectively compete with 3H-estradiol for binding sites while testosterone, dihydrotestosterone, and cortisol do not. The binding component is different from sexhormone-binding-globulin. It is present in these tissues in relatively large amounts and is tentatively identified as an estrogen receptor.Keywords
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