Acitretin (Neotigason®)
- 1 April 1992
- journal article
- review article
- Published by Springer Nature in International Journal of Clinical Pharmacy
- Vol. 14 (2) , 33-37
- https://doi.org/10.1007/bf01980479
Abstract
Acitretin was introduced as a replacement for etretinate, the ethyl ester of acitretin. Acitretin is eliminated at a much faster rate than etretinate. Although both drugs are teratogens, the replacement was important especially as it allowed for a much shorter post-medication period in which pregnancy should be precluded. Recent findings showed the presence of etretinate in the plasma of acitretin-treated patients. This article gives a review of known metabolic pathways of the retinoids and tries to elucidate the possible conversion of acitretin into etretinate after acitretin ingestion.Keywords
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