Effect of endogenous dopamine on extrastriatal [11C]FLB 457 binding measured by PET
- 14 May 2001
- Vol. 41 (2) , 87-95
- https://doi.org/10.1002/syn.1063
Abstract
Central dopaminergic systems are known to be implicated in the pathophysiology of schizophrenia and recent in vivo dopamine receptor imaging studies have focused on the measurement of extrastriatal dopamine receptor. However, there are only a limited number of ligands that can measure the low-density D2 receptor in extrastriatal regions and their sensitivity to endogenous dopamine in extrastriatal regions has not yet been fully examined. In this study, the effect of endogenous dopamine on the extrastriatal binding of [11C]FLB 457 was examined in the rhesus monkey after facilitation with 1 mg/kg of methamphetamine (MAP) and was compared with the effect on the striatal binding of [11C]raclopride. The indices of receptor binding were obtained by four methods using cerebellum as a reference region. The bindings of [11C]FLB 457 in the frontal cortex, temporal cortex, and thalamus were not significantly changed after MAP treatment, while the striatal binding of [11C]raclopride was decreased by more than 20%. These results suggest that [11C]FLB 457 is not sensitive to endogenous dopamine in the extrastriatal regions of rhesus monkeys, despite a sufficient dose of MAP to decrease the binding of [11C]raclopride in the striatum. Synapse 41:87–95, 2001.Keywords
This publication has 39 references indexed in Scilit:
- PET Measures of Amphetamine-Induced Dopamine Release in Ventral versus Dorsal StriatumNeuropsychopharmacology, 1999
- Assessment of Dynamic Neurotransmitter Changes with Bolus or Infusion Delivery of Neuroreceptor LigandsJournal of Cerebral Blood Flow & Metabolism, 1998
- Kinetic Modeling of [11C]Raclopride: Combined PET-Microdialysis StudiesJournal of Cerebral Blood Flow & Metabolism, 1997
- Effect of reserpine-induced depletion of synaptic dopamine on [11C]Raclopride binding to D2-dopamine receptors in the monkey brainSynapse, 1997
- In Vitro Receptor Binding Characteristics of the New Dopamine D2Antagonist [125I]NCO-298: Methodological Considerations of High Affinity BindingJournal of Receptors and Signal Transduction, 1995
- Comparison of three high affinity SPECT radiotracers for the dopamine D2 receptorNuclear Medicine and Biology, 1994
- High affinity dopamine D2 receptor radioligands. 3. [123I] and [125I]epidepride: In vivo studies in rhesus monkey brain and comparison with in vitro pharmacokinetics in rat brainLife Sciences, 1993
- High affinity dopamine D2 receptor radioligands. 2. [125I]epidepride, a potent and specific radioligand for the characterization of striatal and extrastriatal dopamine D2 receptorsLife Sciences, 1991
- Production of 3-N-[11C]methylspiperone with high specific activity and high radiochemical purity for PET studies: Suppression of its radiolysisInternational Journal of Radiation Applications and Instrumentation. Part A. Applied Radiation and Isotopes, 1990
- Kinetic Analysis of Central [11C]Raclopride Binding to D2-Dopamine Receptors Studied by PET—A Comparison to the Equilibrium AnalysisJournal of Cerebral Blood Flow & Metabolism, 1989