Serum anti-gamma-globulin and antinuclear factors in the aged

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Abstract
With use of a standard latex agglutination test, anti-[gamma]-globulin factor was found in the serum of 16% of 325 elderly persons. There was no significant difference in the number of positive reactions between the sexes, but the percentage of seroreactors was higher among Jewish than non-Jewish women. Seventeen of the 52 seroreactors were found to have clinical evidence of rheumatoid arthritis. Antinuclear factor was found in 36% of 255 of these elderly persons. There was no correlation between positive antinuclear and anti-[gamma]-globulin reactions. The concentrations of total serum protein and of serum albumin were slightly lower than those found in healthy young adults, while the concentration of serum [gamma]-globulin was slightly greater.