Palytoxin: A New Marine Toxin from a Coelenterate
- 30 April 1971
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 172 (3982) , 495-498
- https://doi.org/10.1126/science.172.3982.495
Abstract
Palytoxin has been isolated from the zoanthids " limu-make-o-Hana " (Tentatively identified as Palythoa sp.) as a noncrystalline, chromatographically pure entity. Apart from polypeptide and protein toxins, it is the most highly toxic substance known, with a lethal dose (LD 59 ) in mice of 0.15 microgram per kilogram by intravenous injection. Unlike the potent toxins batrachotoxin, saxitoxin, and tetrodotoxin which have molecular weights of 500 or less, palytoxin has an estimated molecular weight of 3300 and contains no repetitive amino acid or sugar units.Keywords
This publication has 4 references indexed in Scilit:
- Structure of batrachotoxin, a steroidal alkaloid from the Colombian arrow poison frog, phyllobates aurotaenia, and partial synthesis of batrachotoxin and its analogs and homologsJournal of the American Chemical Society, 1969
- Aluterin: a Toxin of Filefish, Alutera scripta, Probably Originating from a Zoantharian, Palythoa tuberculosaNIPPON SUISAN GAKKAISHI, 1969
- The venom of the Colombian arrow poison frogPhyllobates bicolorCellular and Molecular Life Sciences, 1963
- Weitere Untersuchungen über das Verhalten quartärer Pyridiniumsalze und quartärer Salze anderer cyclischer Basen gegen Natriumhyposulfit, Na2S2O4Helvetica Chimica Acta, 1938