Hyperthermia and paraquat-induced G1 arrest in the yeastSaccharomyces cerevisiae is independent of the RAD9 gene
- 1 February 1996
- journal article
- research article
- Published by Springer Nature in Radiation and Environmental Biophysics
- Vol. 35 (1) , 55-57
- https://doi.org/10.1007/bf01211243
Abstract
Mutants of the RAD9 gene ofSaccharomyces cerevisiae are defective in cell cycle checkpoint arrest in G1 and G2 after treatment with DNA-damaging agents. It is demonstrated that the pronounced G1 arrest observed in yeast after hyperthermia treatment or exposure to paraquat-generated superoxide radicals does not depend on a functional RAD9 gene. For both types of treatments, the mechanism of cell cycle arrest must be considered different from the activation of the DNA damage checkpoint response.Keywords
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