Hydrolysis products of cisplatin: pK a determinations via[1H, 15N] NMR spectroscopy
- 1 January 1992
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Journal of the Chemical Society, Chemical Communications
- No. 10,p. 789-791
- https://doi.org/10.1039/c39920000789
Abstract
The pKa values of cis-[PtCl(H2O)(NH3)2]+(6.41) and cis-[Pt(H2O)2(NH3)2]2+(5.37 and 7.21) have been determined at 300 K via the use of 15N-edited 1H NMR spectroscopy and [1H, 15N] heteronuclear multiple quantum coherence spectroscopy; this allows rapid measurements at low (millimolar) concentrations, and so avoids some of the problems associated with other methods.Keywords
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