The role of type X collagen in facilitating and regulating endochondral ossification of articular cartilage
- 24 January 2005
- journal article
- review article
- Published by Wiley in Orthodontics & Craniofacial Research
- Vol. 8 (1) , 11-17
- https://doi.org/10.1111/j.1601-6343.2004.00308.x
Abstract
Structured Author – Shen GObjective – This review was compiled to explore the role of type X collagen in growth, development and remodeling of articular cartilage by elucidating the linkage between the synthesis of this protein and the phenotypic changes in chondrogenesis and the onset of endochondral ossification.Design – The current studies closely dedicated to elucidating the role of type X collagen incorporating into chondrogenesis and endochondral ossification of articular cartilage were assessed and analyzed to allow for obtaining the mainstream consensus on the bio‐molecular mechanism with which type X collagen functions in articular cartilage.Results – There are spatial and temporal correlations between synthesis of type X collagen and occurrence of endochondral ossification. The expression of type X collagen is confined within hypertrophic condrocytes and precedes the embark of endochondral bone formation. Type X collagen facilitates endochondral ossification by regulating matrix mineralization and compartmentalizing matrix components.Conclusion – Type X collagen is a reliable marker for new bone formation in articular cartilage. The future clinical application of this collagen in inducing or mediating endochondral ossification is perceived, e.g. the fracture healing of synovial joints and adaptive remodeling of madibular condyle.Keywords
This publication has 41 references indexed in Scilit:
- Effect of compressive forces on extracellular matrix in rat mandibular condylar cartilageJournal of Bone and Mineral Metabolism, 2003
- Localization and inhibitory effect of basic fibroblast growth factor on chondrogenesis in cultured mouse mandibular condyleJournal of Bone and Mineral Metabolism, 2003
- Selective assembly and remodelling of collagens II and IX associated with expression of the chondrocyte hypertrophic phenotypeDevelopmental Dynamics, 2000
- Craniofacial abnormalities in mice carrying a dominant interference mutation in type X collagenDevelopmental Dynamics, 1997
- Abnormal Compartmentalization of Cartilage Matrix Components in Mice Lacking Collagen X: Implications for FunctionThe Journal of cell biology, 1997
- Intron‐exon structure, alternative use of promoter and expression of the mouse collagen X gene,Col10a‐1European Journal of Biochemistry, 1993
- Selective binding of anchorin CII (annexin V) to type II and X collagen and to chondrocalcin (C‐propeptide of type II collagen) Implications for anchoring function between matrix vesicles and matrix proteinsFEBS Letters, 1992
- Cell hypertrophy and type X collagen synthesis in cultured articular chondrocytesExperimental Cell Research, 1991
- Immunoelectron microscopy of type X collagen: Supramolecular forms within embryonic chick cartilageDevelopmental Biology, 1990
- Collagen type IX: Evidence for covalent linkages to type II collagen in cartilageFEBS Letters, 1987