Abstract
"Histamine, that decarboxylated son of histidine" — these poetic words of Carl Dragstedt, the pharmacologist and brother of Lester, the great surgeon, express beautifully the frustrations and disappointments of all who are confirmed histamine addicts. And there are quite a few in the world today. Histamine has been one of my interests for over 40 years, and she has been a fickle mistress. She was discovered as a chemical curiosity in 1907, when she was synthesized in Germany by Windaus and Vogt.1 She was isolated from biologic sources, first from ergot and then from intestinal mucosa by Barger and Dale . . .

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