A choline-devoid diet, carcinogenic in the rat, induces DNA damage and repair

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Abstract
A diet deficient in choline when fed to rats for as few as 3 days resulted in liver DNA damage. The damage could be monitored as alkali-labile lesions using alkaline-sucrose gradients as well as alkaline elution technique. The DNA damage disappered when the choline-defident diet was replaced by a choline-suppleinented diet suggesting the alkali-labile lesions were repairable. Hie DNA damage was detected at a time when no liver cefl death was detectable. Tbe induction of DNA damage in a proliferating liver by the choline-defkient diet may be an early important event leading to initiation of liver carcinogenesis.