Analysis of the Contrast AgentIopamidolin Serum by Capillary Electrophoresis
- 1 November 1995
- journal article
- research article
- Published by Taylor & Francis in Journal of Liquid Chromatography
- Vol. 18 (18-19) , 3825-3831
- https://doi.org/10.1080/10826079508014627
Abstract
A rapid method for the analysis of the contrast agent iopamidol (isovue)in serum by CE is described. The method involves deproteinzation with acetonitrile to remove serum proteins followed by direct capillary zone electrophoresis. It is rapid(about 10 min) and sensitive. Other contrast agents and compounds used for renal function tests such as iohexol, iothalamic acid and p-aminohippuric acid can be detected by the same method. The use of acetonitrile in this method to remove serum proteins results in sample stacking allowing the detection of levels less than 1 mg/L.Keywords
This publication has 6 references indexed in Scilit:
- Sample matrix effects in capillary electrophoresis: II. Acetonitrile deproteinizationJournal of Chromatography A, 1993
- Assay of radiographic contrast agents in mice plasma and testes by high-performance liquid chromatographyAnalytical Chemistry, 1993
- Nephrotoxicity of nonionic low-osmolality versus ionic high-osmolality contrast media: a prospective double-blind randomized comparison in human beings.Radiology, 1993
- Iohexol in Serum Determined by Capillary ElectrophoresisClinical Chemistry, 1992
- Nephrotoxicity of Contrast Media following Cardiac Angiography: Pathogenesis, Clinical Course, and Preventive Measures, Including the Role of Low-Osmolality Contrast MediaAnnals of Pharmacotherapy, 1992