Action of Glycine and a Lysozyme-like Agent from Rabbit Monocytes in Destruction of Brucella.

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Abstract
A lysozyme-like material from rabbit monocytes is described. It acts on glycine-treated brucella to cause lysis and death. When parasitized monocytes containing this agent are treated with low concentrations of glycine, intracellular growth and yields of smooth Brucella melitensis, Rev Is is suppressed. The theory is proposed that intraphagocytic death involves a stepwise alteration of the wall, followed by enzymatic degradation of the mucopolysaccharide component responsible for structural integrity of the bacteria.

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