Natural History of Congenital Leukemia

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Abstract
A mongoloid male was born with stem cell leukemia and mild ABO incompatibility. Transfusion and chemotherapy did not induce remission of the disease or influence its rapidly downhill course. The maternal serum exhibited a cytotoxic antibody against the leukemic cells. After 18 intramuscular injections of maternal serum, neutralized with ABO substances, there followed a remission which has lasted since. The recorded lifespan of true congenital leukemia (91 cases) is from 19 h to 6½ years. The natural role of maternal isoantiserum in spontaneous remissions of congenital leukemia should be considered.

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