Effect of Ascorbic Acid on Guinea Pig Skin Collagen Synthesis: I. Total Collagen

Abstract
A deficiency of ascorbic acid caused a decreased uptake of 3H-proline into guinea pig skin collagen and a further decrease in the 3HO-proline formation; inanition from pair-feeding was not a contributing factor. An anemia developed in the completely deficient animals which was prevented with low levels of ascorbic acid in another group.