THE POSTNATAL DEVELOPMENT OF THE PITUITARY THYROTROPIN-RELEASING HORMONE RECEPTOR IN MALE AND FEMALE RATS
- 1 February 1982
- journal article
- research article
- Published by The Endocrine Society in Endocrinology
- Vol. 110 (2) , 663-664
- https://doi.org/10.1210/endo-110-2-663
Abstract
The density of the pituitary TRH receptor in male and female rats was measured during postnatal development. The younger rats of both sexes exhibited higher [3H]TRH binding than did adults. A comparison of the properties of receptor binding between 4–5 day-old and adult pituitary showed that the increased binding was solely due to an increase in Bmax (maximum binding capacity) and not the KD (binding affinity). In conclusion, these findings demonstrate that the increased TRH-receptor density may be a contributing factor in eliciting exaggerated TSH response to exogenous TRH in neonatal rats.Keywords
This publication has 5 references indexed in Scilit:
- Effects of Triiodothyronine on Thyrotropin-Releasing Hormone-Induced Thyrotropin Release in the Neonatal Rat*Endocrinology, 1980
- The development of estrogen receptor systems in the rat brain and pituitary: Postnatal developmentBrain Research, 1979
- A simple method for the determination of affinity and binding site concentration in receptor binding studiesBiochimica et Biophysica Acta (BBA) - Biomembranes, 1977
- THE DEVELOPMENT OF THE BLOOD SUPPLY OF THE PITUITARY IN THE ALBINO RAT, WITH SPECIAL REFERENCE TO THE PORTAL VESSELS1957
- PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENTJournal of Biological Chemistry, 1951