ON THE MECHANISM OF ACTION OF ALDOSTERONE ON SODIUM TRANSPORT: THE ROLE OF PROTEIN SYNTHESIS
- 1 December 1963
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 50 (6) , 1169-1177
- https://doi.org/10.1073/pnas.50.6.1169
Abstract
The hypothesis is presented that aldosterone regulates active Na+ transport by increasing de novo synthesis of enzymes involved in supplying energy for transport work. The evidence presented in support of this hypothesis included observations on: the relationships between the uptake of H3-aldosterone or its rate of removal and the time- course of action; nuclear localization of H3-aldosterone; specific inhibition of the action of aldosterone by actinomycin D and puromycin; and, elimination of the latent period by pretreatment of substrate-depleted bladders with aldosterone.Keywords
This publication has 20 references indexed in Scilit:
- THE ROLE OF RNA SYNTHESIS IN EARLY ESTROGEN ACTIONProceedings of the National Academy of Sciences, 1963
- Radioprotection by Pressor AmidinesScience, 1963
- Relation of Cortisone and Synthesis of Ribonucleic Acid to Induced and Developmental Enzyme FormationJournal of Biological Chemistry, 1963
- AN EFFECT OF TESTOSTERONE ON AMINO ACID INCORPORATION BY PROSTATIC RIBONUCLEOPROTEIN PARTICLESProceedings of the National Academy of Sciences, 1962
- THE ROLE OF DEOXYRIBONUCLEIC ACID IN RIBONUCLEIC ACID SYNTHESIS, III. THE INHIBITION OF THE ENZYMATIC SYNTHESIS OF RIBONUCLEIC ACID AND DEOXYRIBONUCLEIC ACID BY ACTINOMYCIN D AND PROFLAVINProceedings of the National Academy of Sciences, 1962
- Mechanism of puromycin inhibition of hemoglobin synthesisBiochemical and Biophysical Research Communications, 1962
- A Dissociative Effect of Puromycin on the Pathway of Protein Synthesis by Ehrlich Ascites Tumor CellsJournal of Biological Chemistry, 1962
- INHIBITION BY PUROMYCIN OF AMINO ACID INCORPORATION INTO PROTEINProceedings of the National Academy of Sciences, 1959
- Preparation of Coated Radioautographs by Dipping Sections in Fluid Emulsion.Experimental Biology and Medicine, 1957
- Active Transport of Sodium as the Source of Electric Current in the Short‐circuited Isolated Frog Skin.Acta Physiologica Scandinavica, 1951