Screening test for carcinogenicity of chlorhexidine digluconate and its metabolites.

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Abstract
When bactericidal antiseptics are discharged into the environment, they are degraded but their behavior has not been cleaned. In this paper, carcinogenicity of chlorhexidine digluconate and its seven kinds of metabolites (p-chloraniline, p-chlorophenol, p-chloroacetoanilide, aniline, phenol, pyrocatechol and pyrogallol) were screened with Ames test and liquid rec-assay based on Ashby''s report. Ames test was performed with Salmonella typhimurium TA98 and TA100, and liquid rec-assay was performed with Bacillus subtilis H-17 (Rec+) and M-45 (Rec-). Pg was positive on Ames test and liquid rec-assay, and recognized as positive carcinogenic compound. CPh was positive on Ames test with S-9 mix (+). Pc was found to have positive DNA injury by liquid rec-assay with S-9 mix (+). These results suggest the necessity of discarding counterplan of drugs.

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