Tanikolide, a Toxic and Antifungal Lactone from the Marine Cyanobacterium Lyngbya majuscula
- 27 August 1999
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Natural Products
- Vol. 62 (9) , 1333-1335
- https://doi.org/10.1021/np990162c
Abstract
A new brine-shrimp toxic and antifungal compound, tanikolide 1, has been isolated from the lipid extract of a Madagascan collection of the marine cyanobacterium Lyngbyamajuscula. The structure of tanikolide was determined by spectroscopic methods, relying heavily on 2D NMR spectroscopy. The absolute configuration at C-5 of tanikolide was established as R by oxidizing the primary alcohol to an acid and analyzing the corresponding (R)- and (S)-PGME amide derivatives by 1H NMR.Keywords
This publication has 11 references indexed in Scilit:
- Carmabins A and B, New Lipopeptides from the Caribbean Cyanobacterium Lyngbya majusculaJournal of Natural Products, 1998
- Barbamide, a Chlorinated Metabolite with Molluscicidal Activity from the Caribbean Cyanobacterium Lyngbya majusculaJournal of Natural Products, 1996
- Antillatoxin: An Exceptionally Ichthyotoxic Cyclic Lipopeptide from the Tropical Cyanobacterium Lyngbya majusculaJournal of the American Chemical Society, 1995
- Malyngamide H, an Ichthyotoxic Amide Possessing a New Carbon Skeleton from the Caribbean Cyanobacterium Lyngbya majusculaJournal of Natural Products, 1995
- New chiral anisotropic reagents for determining the absolute configuration of carboxylic acidsTetrahedron Letters, 1995
- Structure of Curacin A, a Novel Antimitotic, Antiproliferative and Brine Shrimp Toxic Natural Product from the Marine Cyanobacterium Lyngbya majusculaThe Journal of Organic Chemistry, 1994
- Novel cytotoxic peptides from the tropical marine cyanobacteriumHormothamnion enteromorphoides 1. Discovery, isolation and initial chemical and biological characterization of the hormothamnins from wild and cultured materialCellular and Molecular Life Sciences, 1989
- Papaver bracteatum, influence d'un traitement réfrigérant et du clonage sur la teneur en thébaïne des capsulesPlanta Medica, 1982
- Brine Shrimp: A Convenient General Bioassay for Active Plant ConstituentsPlanta Medica, 1982
- Structure and absolute configuration of malyngolide, an antibiotic from the marine blue-green alga Lyngbya majuscula GomontThe Journal of Organic Chemistry, 1979