STUDIES ON EPILEPSY

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Abstract
The susceptibility of cats to convulsive seizures from absinth was increased whenever intracranial pressure was raised by the intravenous injection of distilled water or the intracranial injection of vaseline or paraffin, and much smaller doses of the convulsing agent were required to produce tonic and clonic convulsive seizures. On the other hand, the susceptibility of the animals was diminished after intracranial pressure had been lowered by intravenous injection of hypertonic solutions. The experiments showed that variations in intracranial pressure have a decided effect, although it is as yet impossible to state whether this is due to the increase or decrease of intracranial pressure itself or occurs secondarily through an effect upon the circulation of blood (and perhaps of other fluids) in the motor areas of the cortex and the subcortical pathways.

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