FILIPIN-POSITIVE, OIL RED O-NEGATIVE PARTICLES IN ATHEROSCLEROTIC LESIONS INDUCED BY CHOLESTEROL FEEDING
- 1 January 1984
- journal article
- research article
- Vol. 50 (1) , 87-93
Abstract
Extracellular spherical filipin-positive particles were demonstrated using the fluorescent cholesterol probe, filipin, in rat, rabbit and monkey atherosclerotic lesions induced by cholesterol feeding. Examination of tissue sections stained with both filipin (detects unesterified cholesterol) and oil red O (detects esterified cholesterol) demonstrated that extracellular filipin-positive particles did not stain with oil red O. Extracellular filipin-positive particles represent a previously unrecognized structure in which cholesterol accumulates within atherosclerotic lesions.This publication has 10 references indexed in Scilit:
- DISTRIBUTION OF INTRAMEMBRANE PARTICLES AND FILIPIN-STEROL COMPLEXES IN PLASMA-MEMBRANES OF KIDNEY .1. CORPUSCLE OF MALPIGHI1982
- Analysis of membrane structure in the transitional epithelium of rat urinary bladder. 3. Localization of cholesterol using filipin and digitoninJournal of Ultrastructure Research, 1981
- Evaluation of the polyene antibiotic filipin as a cytochemical probe for membrane cholesterol.Journal of Histochemistry & Cytochemistry, 1980
- Quantification of low density lipoprotein binding and cholesterol accumulation by single human fibroblasts using fluorescence microscopy.Journal of Lipid Research, 1980
- ATHEROSCLEROSIS IN THE ERYTHROCEBUS-PATAS, AN OLD-WORLD MONKEY1980
- Membrane sterol heterogeneity. Freeze-fracture detection with saponins and filipin.Journal of Histochemistry & Cytochemistry, 1979
- Lack of effect of an antifibrinolytic agent on cholesterol-induced aortic lesions in the rat, with observations on the independence of intimal foam cell lesions and extracellular medial lipidExperimental and Molecular Pathology, 1979
- Simultaneous gelatin embedding of multiple areas of the arterial treeAtherosclerosis, 1977
- ABSENCE OF ENHANCED INTIMAL THICKENING IN RESPONSE OF CAROTID ARTERIAL-WALL TO ENDOTHELIAL INJURY IN HYPERCHOLESTEROLEMIC RATS1976
- Induced Hypercholesterolemia and AtherogenesisCirculation, 1952