Alteration of the Redox State of Nadph and Glutathione in Perfused Rabbit Lung By Paraquat
- 1 October 1986
- journal article
- Published by SAGE Publications in Toxicology and Industrial Health
- Vol. 2 (4) , 417-428
- https://doi.org/10.1177/074823378600200405
Abstract
The glutathione and NADP + status of perfused rabbit lung was deter mined both before and after perfusion with 1 mM paraquat. The pul monary glutathione redox state was similar to that of liver, having a glutathione/glutathione disulfide ratio of about 240. This ratio was lower in lungs perfused with glucose-free medium, a condition in which NADPH probably becomes limiting. Perfusion with paraquat signifi cantly increased the pulmonary glutathione disulfide content, particu larly in the absence of glucose, resulting in a glutathionelglutathione disulfide ratio ofKeywords
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