Cell susceptibility to transformation and cytotoxicity by the carcinogenic hydrocarbon benzo[a]pyrene.
- 1 October 1966
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 56 (4) , 1123-1129
- https://doi.org/10.1073/pnas.56.4.1123
Abstract
It was shown that there is a one-hit dose response curve for transformation by the carcinogenic hydrocarbon benzo[a] pyrene (BP), and that transformation and cytotoxicity by BP are 2 different events. Results obtained with isolated clones indicate that normal hamster clones can be either resistant or susceptible to cytotoxicity by BP; that transformation can be obtained with both types of clones; that there is a hereditary and a physiological state of competence to transformation; and that the morphology of the normal cell type that is transformed is a major factor in controlling the morphology of the transformed colony.Keywords
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