Observations on Monomethylaminoethanol and Dimethylaminoethanol in the Diet of Chicks

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Abstract
Monomethylaminoethanol and dimethylaminoethanol were found to prevent perosis in chicks when added to a purified diet which was deficient in choline. Growth was promoted by dimethylaminoethanol but not by monomethylaminoethanol. The addition of methionine to the diet did not stimulate growth but growth was increased when methionine was added to the basal diet plus monomethylaminoethanol or to the basal diet plus dimethylaminoethanol. Experiments were also made with a basal diet deficient in both methionine and choline. Growth was not stimulated by dimethylaminoethanol unless methionine was also added. Chicks receiving the basal diet did not develop perosis, but perosis developed in chicks receiving the basal diet plus methionine. These observations are compared with certain results which have been reported in experiments with the rat and with the “cholineless” mutant no. 34486 of Neurospora crassa.