Progression of vinyl chloride induced hepatic fibrosis to angiosarcoma of the liver

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Abstract
Two vinyl chloride monomer (VCM) workers, who developed non-cirrhotic portal fibrosis and portal hypertension, died from angiosarcoma of the liver five and ten years later respectively, despite withdrawal from occupational exposure. We suggest that non-cirrhotic portal fibrosis caused by exposure to VCM is potentially premalignant and that those workers who already have the condition should be carefully monitored.