COEXISTENCE OF DONOR AND HOST T LYMPHOCYTES FOLLOWING HLA-DIFFERENT BONE MARROW TRANSPLANTATION INTO A PATIENT WITH CELLULAR IMMUNODEFICIENCY AND NONFUNCTIONAL CD4+ T CELLS

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Abstract
We report the outcome of a non-T-cell-depleted bone marrow transplant from an HLA partially incompatible, MLR-positive, parental donor in a patient with an unusual form of immunodeficiency characterized by a lack of CD8 T cells and a failure of the CD4 cells to display functional activity in vitro. Without conditioning, and following a mild and transient GVHD, donor T cells persist in trace amounts in the host, where they coexist with the nonfunctional host T cells and cooperate with host APC in antigen recognition, thereby leading to a reconstitution of T cell functions in vitro and in vivo and development of a stable, so far unprecedented, human T-T split chimera across MHC barriers.

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