A Unifying Mutation in Chronic Myeloproliferative Disorders

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Abstract
In 1892, Louis Vaquez of Paris described a patient with cyanotic polycythemia; the autopsy disclosed massive enlargement of the spleen and liver. In 1903, William Osler, then at Johns Hopkins Hospital, reported on four patients with polycythemia, two of whom had splenomegaly. He gave credit to Vaquez for the earlier description, and the disorder was later named Osler–Vaquez disease, though today it is usually referred to as polycythemia vera.In 1951, William Dameshek drew attention to the relationships among polycythemia vera, idiopathic myelofibrosis, and essential thrombocythemia and proposed that these diseases, as well as chronic myeloid leukemia and erythroleukemia, should . . .

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