EFFECT OF ESTRACYT ON RAT PROSTATE

  • 1 January 1977
    • journal article
    • research article
    • Vol. 14  (5) , 400-404
Abstract
Two types of experiments were performed to elucidate the estrogenic effect of estracyt on immature rats that had received injections of testosterone. Changes in weight of accessory sex organs, body weight, ventral and the dorsolateral prostates, and adrenal gland, and changes in activities of testosterone 5.alpha.-reductase, alkaline phosphatase and arginase of both lobes of the prostates were examined. Estracyt was injected into castrated rats and immature rats that had received injections of testosterone; changes in weight of accessory sex organs were determined. Because similar changes were induced by treatment of animals with estradiol-17.beta., the effect of estracyt on the prostates was most likely due to the estrogenic effect of the drug.

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