Proposal concerning mechanism of evolution of the genome of Escherichia coli.
- 1 April 1975
- journal article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 72 (4) , 1354-1358
- https://doi.org/10.1073/pnas.72.4.1354
Abstract
Many pairs of genes whose gene products are functionally related lie either 90 degrees or 180 degrees apart on the circular map of the E. coli chromosome. A mechanism of evolution is proposed that involves two sequential duplications of an ancestral genome, followed by mutation and divergence of function of replicate genes.Keywords
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