ELEVATED CEREBELLAR CYCLIC-GMP LEVELS DURING THE DELTAMETHRIN-INDUCED MOTOR SYNDROME

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  • 1 January 1982
    • journal article
    • research article
    • Vol. 4  (1) , 109-113
Abstract
Adult male Porton albino rats received the insecticide deltamethrin (0.5-40.0 mg/kg i.p.) or glycerol formal solvent. Their behavior was observed during the subsequent 110 min and the incidence and latency of salivation, tremor and incoordination and spontaneous choreiform episodes were noted. cGMP levels in the cerebellum were determined by radioimmunoassay at various times after deltamethrin administration. The development of the motor syndrome was dose-dependent and followed a specific time course. The threshold dose for profuse salivation and tremor and incoordination was 2.5 mg/kg i.p., and for spontaneous choreiform episodes, 5.0 mg/kg i.p. The latency of tremor and incoordination decreased significantly as the dose increased. The 1st significant increase in cGMP levels in the cerebellum was at 70 min, which was 10 min after the mean latency of tremor and incoordination. The levels increased further at 100 min, which was .apprx. 20 min after the mean latency of spontaneous choreiform episodes. Deltamethrin did not have a dose-dependent effect on cGMP levels. Deltamethrin changed cerebellar cGMP levels indirectly.