Release of Methotrexate from Microsphere-In-Oil-In-Water Emulsions

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Abstract
The in vivo and in vitro release characteristics of methotrexate from the microsphere-in-oil-in-water emulsions were studied. The results demonstrated a rapid and slow biphasic release profiles for the emulsions. This may be due to the release of methotrexate from the external aqueous phase of the emulsion for the rapid release phase and from the internal microsphere for the slow release phase. The addition of phosphatidylcholine in the emulsions resulted in a slower release of the methotrexate which may be caused by the formation of phospholipid layers on the surface of the emulsion particles to hinder the release of the drug from the emulsions.